Nucleotide Modification Alters MicroRNA-Dependent Silencing of MicroRNA Switches

• Main Authors: John Lockhart (Author), John Canfield (Author), Ezinne Francess Mong (Author), Jeffrey VanWye (Author), Hana Totary-Jain (Author)
• Formato: Livro
• Publicado em: Elsevier, 2019-03-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

mRNA therapeutics hold great promise for the treatment of human diseases. While incorporating naturally occurring modified nucleotides during synthesis has greatly increased their potency and safety, challenges in selective expression have hindered clinical applications. MicroRNA (miRNA)-regulated i...