Effects of a Novel Histone Deacetylase Inhibitor, N-(2-Aminophenyl) Benzamide, on a Reversible Hypertrophy Induced by Isoproterenol in In Situ Rat Hearts

• Main Authors: Yutaka Kitagawa (Author), Yamato Tamura (Author), Juichiro Shimizu (Author), Chikako Nakajima-Takenaka (Author), Shigeki Taniguchi (Author), Shinichi Uesato (Author), Miyako Takaki (Author)
• Formato: Livro
• Publicado em: Elsevier, 2007-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The aim of the present study was performed to determine whether a novel histone deacetylase (HDAC) inhibitor, N-(2-aminophenyl)-4-{[benzyl(2-hydroxyethyl)amino]methyl} benzamide (K-183), prevents a reversible cardiac hypertrophy induced by isoproterenol and improves left ventricular (LV) dysfunction...