Gelofusine Attenuates Tubulointerstitial Injury Induced by cRGD-Conjugated siRNA by Regulating the TLR3 Signaling Pathway

• Main Authors: Bohong Cen (Author), Wenjie Liao (Author), Zhen Wang (Author), Linyuan Gao (Author), Yuanyi Wei (Author), Wen Huang (Author), Shuai He (Author), Wei Wang (Author), Xiaoxia Liu (Author), Xinghua Pan (Author), Aimin Ji (Author)
• Format: Book
• Published: Elsevier, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Integrin αvβ3, which is selectively targeted by cyclic arginine-glycine-aspartic acid (cRGD) peptides, is significantly upregulated in tumors. Previous studies showed that small interfering RNA (siRNA) modified with cRGD (cRGD-siRNA) could significantly inhibit tumor growth through RNAi with oncogen...