Ginsenoside Rg1 ameliorates blood-brain barrier disruption and traumatic brain injury via attenuating macrophages derived exosomes miR-21 release

• Main Authors: Kefeng Zhai (Author), Hong Duan (Author), Wei Wang (Author), Siyu Zhao (Author), Ghulam Jilany Khan (Author), Mengting Wang (Author), Yuhan Zhang (Author), Kiran Thakur (Author), Xuemei Fang (Author), Chao Wu (Author), Jianbo Xiao (Author), Zhaojun Wei (Author)
• Format: Book
• Published: Elsevier, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

During the traumatic brain injury (TBI), improved expression of circulatory miR-21 serves as a diagnostic feature. Low levels of exosome-miR-21 in the brain can effectively improve neuroinflammation and blood-brain barrier (BBB) permeability, reduce nerve apoptosis, restore neural function and ameli...