The Late-Stage Protective Effect of Mito-TEMPO against Acetaminophen-Induced Hepatotoxicity in Mouse and Three-Dimensional Cell Culture Models

• मुख्य लेखकों: Mohammad Abdullah- (लेखक), Kenta Sasaki (लेखक), Saori Kikutani (लेखक), Nanami Namba (लेखक), Keiichi Ueno (लेखक), Yuki Kondo (लेखक), Hitoshi Maeda (लेखक), Toru Maruyama (लेखक), Tetsumi Irie (लेखक), Yoichi Ishitsuka (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2020-10-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

An overdose of acetaminophen (APAP), the most common cause of acute liver injury, induces oxidative stress that subsequently causes mitochondrial impairment and hepatic necroptosis. N-acetyl-L-cysteine (NAC), the only recognized drug against APAP hepatotoxicity, is less effective the later it is adm...