The Late-Stage Protective Effect of Mito-TEMPO against Acetaminophen-Induced Hepatotoxicity in Mouse and Three-Dimensional Cell Culture Models

• Main Authors: Mohammad Abdullah- (Author), Kenta Sasaki (Author), Saori Kikutani (Author), Nanami Namba (Author), Keiichi Ueno (Author), Yuki Kondo (Author), Hitoshi Maeda (Author), Toru Maruyama (Author), Tetsumi Irie (Author), Yoichi Ishitsuka (Author)
• Format: Book
• Published: MDPI AG, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

An overdose of acetaminophen (APAP), the most common cause of acute liver injury, induces oxidative stress that subsequently causes mitochondrial impairment and hepatic necroptosis. N-acetyl-L-cysteine (NAC), the only recognized drug against APAP hepatotoxicity, is less effective the later it is adm...