Lack of resolution sensor drives age-related cardiometabolic and cardiorenal defects and impedes inflammation-resolution in heart failure

• Main Authors: Bochra Tourki (Author), Vasundhara Kain (Author), Amanda B. Pullen (Author), Paul C. Norris (Author), Nirav Patel (Author), Pankaj Arora (Author), Xavier Leroy (Author), Charles N. Serhan (Author), Ganesh V. Halade (Author)
• Format: Book
• Published: Elsevier, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Recently, we observed that the specialized proresolving mediator (SPM) entity resolvin D1 activates lipoxin A4/formyl peptide receptor 2 (ALX/FPR2), which facilitates cardiac healing and persistent inflammation is a hallmark of impaired cardiac repair in aging. Splenic leukocyte-directed...