Cancer resistance via the downregulation of the tumor suppressors RKIP and PTEN expressions: therapeutic implications

• Autori principali: Matthew Moghaddam (Autore), Silvia Vivarelli (Autore), Luca Falzone (Autore), Massimo Libra (Autore), Benjamin Bonavida (Autore)
• Natura: Libro
• Pubblicazione: Open Exploration Publishing Inc., 2023-04-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

The Raf kinase inhibitor protein (RKIP) has been reported to be underexpressed in many cancers and plays a role in the regulation of tumor cells' survival, proliferation, invasion, and metastasis, hence, a tumor suppressor. RKIP also regulates tumor cell resistance to cytotoxic drugs/cells. Lik...