Cancer resistance via the downregulation of the tumor suppressors RKIP and PTEN expressions: therapeutic implications

• Main Authors: Matthew Moghaddam (Author), Silvia Vivarelli (Author), Luca Falzone (Author), Massimo Libra (Author), Benjamin Bonavida (Author)
• Format: Book
• Published: Open Exploration Publishing Inc., 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The Raf kinase inhibitor protein (RKIP) has been reported to be underexpressed in many cancers and plays a role in the regulation of tumor cells' survival, proliferation, invasion, and metastasis, hence, a tumor suppressor. RKIP also regulates tumor cell resistance to cytotoxic drugs/cells. Lik...