Absence of microsatellite instability in extramammary Paget's disease

• Main Authors: K. Kashiwada‐Nakamura (Author), T. M. Myangat (Author), I. Kajihara (Author), Y. Kusaba (Author), K. Tanaka (Author), R. Sakamoto (Author), S. Maeda‐Otsuka (Author), S. Yamada‐Kanazawa (Author), S. Sawamura (Author), H. Kanemaru (Author), Y. Nishimura (Author), N. Honda (Author), K. Makino (Author), A. Miyashita (Author), J. Aoi (Author), T. Igata (Author), T. Makino (Author), S. Masuguchi (Author), S. Fukushima (Author), H. Ihn (Author)
• Format: Book
• Published: Wiley, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Deficiency of DNA mismatch repair (MMR) induces microsatellite instability (MSI). Pembrolizumab, an antibody targeting PD‐1 (an immune checkpoint inhibitor), is more effective against MMR‐deficient tumours than against MMR‐proficient tumours. The status of MMR is a useful biomark...