Neurturin is a PGC-1α1-controlled myokine that promotes motor neuron recruitment and neuromuscular junction formation

• Main Authors: Richard Mills (Author), Hermes Taylor-Weiner (Author), Jorge C. Correia (Author), Leandro Z. Agudelo (Author), Ilary Allodi (Author), Christina Kolonelou (Author), Vicente Martinez-Redondo (Author), Duarte M.S. Ferreira (Author), Susanne Nichterwitz (Author), Laura H. Comley (Author), Vanessa Lundin (Author), Eva Hedlund (Author), Jorge L. Ruas (Author), Ana I. Teixeira (Author)
• Format: Book
• Published: Elsevier, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: We examined whether skeletal muscle overexpression of PGC-1α1 or PGC-1α4 affected myokine secretion and neuromuscular junction (NMJ) formation. Methods: A microfluidic device was used to model endocrine signaling and NMJ formation between primary mouse myoblast-derived myotubes and embryo...