Murine cancer cachexia models replicate elevated catabolic pembrolizumab clearance in humans

• मुख्य लेखकों: Alyssa Marie M. Castillo (लेखक), Trang T. Vu (लेखक), Sophia G. Liva (लेखक), Min Chen (लेखक), Zhiliang Xie (लेखक), Justin Thomas (लेखक), Bryan Remaily (लेखक), Yizhen Guo (लेखक), Uma L. Subrayan (लेखक), Travis Costa (लेखक), Timothy H. Helms (लेखक), Donald J. Irby (लेखक), Kyeongmin Kim (लेखक), Dwight H. Owen (लेखक), Samuel K. Kulp (लेखक), Thomas A. Mace (लेखक), Mitch A. Phelps (लेखक), Christopher C. Coss (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Wiley, 2021-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Background Monoclonal antibody (mAb) immune checkpoint inhibitor (ICI) therapies have dramatically impacted oncology this past decade. However, only about one‐third of patients respond to treatment, and biomarkers to predict responders are lacking. Recent ICI clinical pharmacology data demo...