Structure-guided design and cloning of peptide inhibitors targeting CDK9/cyclin T1 protein-protein interaction

• Main Authors: Mohammad Sadegh Taghizadeh (Author), Mohsen Taherishirazi (Author), Ali Niazi (Author), Alireza Afsharifar (Author), Ali Moghadam (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

CDK9 (cyclin-dependent kinase 9) plays a significant role in numerous pathological conditions, such as HIV-1 infection and cancer. The interaction between CDK9 and cyclin T1 is crucial for maintaining the kinase's active state. Therefore, targeting this protein-protein interaction offers a prom...