The angiotensin II receptor-neprilysin inhibitor LCZ696 attenuates the progression of proteinuria in type 2 diabetic rats

• Main Authors: Asadur Rahman (Author), Shamshad J. Sherajee (Author), Kazi Rafiq (Author), Hideki Kobara (Author), Tsutomu Masaki (Author), Daisuke Nakano (Author), Takashi Morikawa (Author), Yoshio Konishi (Author), Masahito Imanishi (Author), Akira Nishiyama (Author)
• Format: Book
• Published: Elsevier, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We examined the effects of the angiotensin receptor-neprilysin inhibitor LCZ696 on overt proteinuria and renal injury in type 2 diabetic Otsuka-Long- Evans-Tokushima-Fatty (OLETF) rats. Aged OLETF rats were also treated with either valsartan or valsartan plus hydralazine for comparison. LCZ696 cause...