Transcriptome analysis of human peripheral blood mononuclear cells exposed to Lassa virus and to the attenuated Mopeia/Lassa reassortant 29 (ML29), a vaccine candidate.

• Main Authors: Juan Carlos Zapata (Author), Ricardo Carrion (Author), Jean L Patterson (Author), Oswald Crasta (Author), Yan Zhang (Author), Sachin Mani (Author), Marti Jett (Author), Bhawna Poonia (Author), Mahmoud Djavani (Author), David M White (Author), Igor S Lukashevich (Author), Maria S Salvato (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lassa virus (LASV) is the causative agent of Lassa Fever and is responsible for several hundred thousand infections and thousands of deaths annually in West Africa. LASV and the non-pathogenic Mopeia virus (MOPV) are both rodent-borne African arenaviruses. A live attenuated reassortant of MOPV and L...