Pharmacology of DB844, an orally active aza analogue of pafuramidine, in a monkey model of second stage human African trypanosomiasis.

• Main Authors: John K Thuita (Author), Michael Z Wang (Author), John M Kagira (Author), Cathrine L Denton (Author), Mary F Paine (Author), Raymond E Mdachi (Author), Grace A Murilla (Author), Shelley Ching (Author), David W Boykin (Author), Richard R Tidwell (Author), James E Hall (Author), Reto Brun (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Novel drugs to treat human African trypanosomiasis (HAT) are still urgently needed despite the recent addition of nifurtimox-eflornithine combination therapy (NECT) to WHO Model Lists of Essential Medicines against second stage HAT, where parasites have invaded the central nervous system (CNS). The...