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Pharmacology of DB844, an orally active aza analogue of pafuramidine, in a monkey model of second stage human African trypanosomiasis.

Novel drugs to treat human African trypanosomiasis (HAT) are still urgently needed despite the recent addition of nifurtimox-eflornithine combination therapy (NECT) to WHO Model Lists of Essential Medicines against second stage HAT, where parasites have invaded the central nervous system (CNS). The...

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Main Authors: John K Thuita (Author), Michael Z Wang (Author), John M Kagira (Author), Cathrine L Denton (Author), Mary F Paine (Author), Raymond E Mdachi (Author), Grace A Murilla (Author), Shelley Ching (Author), David W Boykin (Author), Richard R Tidwell (Author), James E Hall (Author), Reto Brun (Author)
Format: Book
Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
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