Mouse Organic Anion Transporter 2 (mOat2) Mediates the Transport of Short Chain Fatty Acid Propionate

• Main Authors: Rafiqul Islam (Author), Naohiko Anzai (Author), Nesar Ahmed (Author), Babu Ellapan (Author), Chun Ji Jin (Author), Sunena Srivastava (Author), Daisaku Miura (Author), Toshiyuki Fukutomi (Author), Yoshikatsu Kanai (Author), Hitoshi Endou (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, we have elucidated that propionate, one of the short chain fatty acids (SCFAs), is the transport substrate for murine organic anion transporter 2 (mOat2), which is expressed in the kidneys and the liver. When expressed in Xenopus oocytes, mOat2-mediated [3H]PGE2transport was inhibited...