Model‐based prediction of effective target exposure for MEN1611 in combination with trastuzumab in HER2‐positive advanced or metastatic breast cancer patients

Abstract MEN1611 is a novel orally bioavailable PI3K inhibitor currently in clinical development for patients with HER2‐positive (HER2+) PI3KCA mutated advanced/metastatic breast cancer (BC) in combination with trastuzumab (TZB). In this work, a translational model‐based approach to determine the mi...

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Main Authors: Elena M. Tosca (Author), Elisa Borella (Author), Chiara Piana (Author), Salim Bouchene (Author), Giuseppe Merlino (Author), Alessio Fiascarelli (Author), Paolo Mazzei (Author), Paolo Magni (Author)
Format: Book
Published: Wiley, 2023-11-01T00:00:00Z.
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