Antitumor Effects of Pegylated Zinc Protoporphyrin-Mediated Sonodynamic Therapy in Ovarian Cancer

• Main Authors: Jia Li (Author), Zheng Hu (Author), Jiwei Zhu (Author), Xin Lin (Author), Xu Gao (Author), Guixiang Lv (Author)
• Format: Bog
• Udgivet: MDPI AG, 2023-09-01T00:00:00Z.
• Fag: article
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Sonodynamic therapy (SDT) induces reactive oxygen species (ROS) to kill tumor cells. Heme oxygenase-1 (HO-1), as an important antioxidant enzyme, resists killing by scavenging ROS. Zinc protoporphyrin (ZnPP) not only effectively inhibits HO-1 activity, but also becomes a potential sonosensitizer. Ho...