Structure-activity relationships of fraxamoside as an unusual xanthine oxidase inhibitor

• Κύριοι συγγραφείς: Rosa Maria Vitale (Συγγραφέας), Lina Antenucci (Συγγραφέας), Margherita Gavagnin (Συγγραφέας), Gennaro Raimo (Συγγραφέας), Pietro Amodeo (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Fraxamoside, a macrocyclic secoiridoid glucoside featuring a hydroxytyrosol group, was recently identified as a xanthine oxidase inhibitor (XOI) comparable in potency in vitro to the standard antigout drug allopurinol. However, this activity and its considerably higher value than its derivatives ole...