Enantioselective aza-Michael Cyclization Reaction Catalyzed by Quinine-Derived Monoquaternary Ammonium Salts: an Effective Route to Synthesize Letermovir

• Main Authors: Liang Chen (Author), Wei-Yuan Liu (Author), Si-Ju Bi (Author), Ting Zhou (Author), Jing Pan (Author), Xun-Lei Lv (Author), Kuai-Le Lin (Author), Wei-Cheng Zhou (Author)
• Format: Book
• Published: Georg Thieme Verlag KG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract A series of mono- or bis-quaternary ammonium salts derived from cinchonidine or quinine was synthesized and screened as potent phase-transfer catalysts for the reaction of aza-Michael cyclization, the key step in the synthesis of letermovir. During the reaction of aza-Michael cyclization, t...