Phenotypic rescue of a Drosophila model of mitochondrial ANT1 disease

• Main Authors: Suvi Vartiainen (Author), Shanjun Chen (Author), Jack George (Author), Tea Tuomela (Author), Kaisa R. Luoto (Author), Kevin M. C. O'Dell (Author), Howard T. Jacobs (Author)
• Format: Book
• Published: The Company of Biologists, 2014-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A point mutation in the Drosophila gene that codes for the major adult isoform of adenine nuclear translocase (ANT) represents a model for human diseases that are associated with ANT insufficiency [stress-sensitive B1 (sesB1)]. We characterized the organismal, bioenergetic and molecular phenotype of...