Mutations Selectively Evolving Peroxidase Activity Among Alternative Catalytic Functions of Human Glutathione Transferase P1-1

• Autors principals: Aram Ismail (Autor), Bengt Mannervik (Autor)
• Format: Llibre
• Publicat: MDPI AG, 2024-11-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Glutathione transferases are detoxication enzymes with broad catalytic diversity, and small alterations to the protein's primary structure can have considerable effects on the enzyme's substrate selectivity profile. We demonstrate that two point mutations in glutathione transferase P1-1 su...