Duration of prior psychotic illness and clozapine response: a retrospective observational study using electronic health records

• Main Authors: Rowena Jones (Author), Rachel Upthegrove (Author), Malcolm J. Price (Author), Megan Pritchard (Author), Joht Singh Chandan (Author), Sophie Legge (Author), James H. MacCabe (Author)
• Format: Book
• Published: SAGE Publishing, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Clozapine is the gold-standard medication for treatment-resistant schizophrenia (TRS) yet its initiation is often delayed. Objective: To examine whether earlier initiation of clozapine in TRS is associated with lower Clinical Global Impression - Severity (CGI-S) scores at 2 years. Method...