Discovery of N-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase B

• Main Authors: Ahmed Elkamhawy (Author), Sora Paik (Author), Hyeon Jeong Kim (Author), Jong-Hyun Park (Author), Ashwini M. Londhe (Author), Kyeong Lee (Author), Ae Nim Pae (Author), Ki Duk Park (Author), Eun Joo Roh (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Herein, two new series of N-substituted indole-based analogues were rationally designed, synthesized via microwave heating technology, and evaluated as noteworthy MAO-B potential inhibitors. Compared to the reported indazole-based hits VI and VII, compounds 4b and 4e exhibited higher inhibitory acti...