Binding, Neutralization and Internalization of the Interleukin-13 Antibody, Lebrikizumab

• Main Authors: Angela J. Okragly (Author), Aya Ryuzoji (Author), Isabella Wulur (Author), Montanea Daniels (Author), Robert D. Van Horn (Author), Chetan N. Patel (Author), Robert J. Benschop (Author)
• Format: Book
• Published: Adis, Springer Healthcare, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Introduction IL-13 is the primary upregulated cytokine in atopic dermatitis (AD) skin and is the pathogenic mediator driving AD pathophysiology. Lebrikizumab, tralokinumab and cendakimab are therapeutic monoclonal antibodies (mAb) that target IL-13. Methods We undertook studies to compare i...