ALS-linked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modulating BCL2-BECN1 interaction

• Main Authors: Shiqiang Xu (Author), Qilian Ma (Author), Junwen Shen (Author), Ningning Li (Author), Shan Sun (Author), Nana Wang (Author), Yang Chen (Author), Chunsheng Dong (Author), Kin Yip Tam (Author), Jochen H.M. Prehn (Author), Hongfeng Wang (Author), Zheng Ying (Author)
• Format: Book
• Published: Elsevier, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Growing evidences indicate that dysfunction of autophagy contributes to the disease pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two neurodegenerative disorders. The GGGGCC·GGCCCC repeat RNA expansion in chromosome 9 open reading frame 72 (C9orf72) is the mo...