Investigation of monoclonal antibody dimers in a final formulated drug by separation techniques coupled to native mass spectrometry

• Main Authors: G. Rouby (Author), N. T. Tran (Author), Y. Leblanc (Author), M. Taverna (Author), N. Bihoreau (Author)
• פורמט: ספר
• יצא לאור: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Therapeutic monoclonal antibodies (mAbs) are highly complex proteins that must be exhaustively characterized according to the regulatory authorities' recommendations. MAbs display micro-heterogeneity mainly due to their post-translational modifications, but also to their susceptibility to chemi...