Application of a Physiologically Based Pharmacokinetic Model to Develop a Veterinary Amorphous Enrofloxacin Solid Dispersion

• Main Authors: Kaixiang Zhou (Author), Meixia Huo (Author), Wenjin Ma (Author), Kun Mi (Author), Xiangyue Xu (Author), Samah Attia Algharib (Author), Shuyu Xie (Author), Lingli Huang (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Zoonotic intestinal pathogens threaten human health and cause huge economic losses in farming. Enrofloxacin (ENR) shows high antibacterial activity against common intestinal bacteria. However, its poor palatability and low aqueous solubility limit the clinical application of ENR. To obtain an ENR or...