Reduction of pro-tumorigenic activity of human prostate cancer-associated fibroblasts using Dlk1 or SCUBE1

• Main Authors: Brigid Orr (Author), O. Cathal Grace (Author), Pam Brown (Author), Antony C. P. Riddick (Author), Grant D. Stewart (Author), Omar E. Franco (Author), Simon W. Hayward (Author), Axel A. Thomson (Author)
• Format: Book
• Published: The Company of Biologists, 2013-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Human prostatic cancer-associated fibroblasts (CAFs) can elicit malignant changes in initiated but non-tumorigenic human prostate epithelium, demonstrating that they possess pro-tumorigenic properties. We set out to reduce the pro-tumorigenic activity of patient CAFs using the Dlk1 and SCUBE...