Microglial depletion exacerbates axonal damage and motor dysfunction in mice with cuprizone-induced demyelination

• Main Authors: Shinji Yamamoto (Author), Kensuke Iwasa (Author), Anzu Yamagishi (Author), Chikara Haruta (Author), Kei Maruyama (Author), Keisuke Yoshikawa (Author)
• Format: Book
• Published: Elsevier, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The cuprizone (CPZ)-induced demyelination model, an animal model of Multiple sclerosis (MS), is characterized by demyelination and motor dysfunction due to microglial-mediated neuroinflammation. To determine the contribution of microglia to motor function during CPZ-induced demyelination, the microg...