Association of genetic variants in the promoter region of genes encoding p22phox (<it>CYBA</it>) and glutamate cysteine ligase catalytic subunit (<it>GCLC</it>) and renal disease in patients with type 1 diabetes mellitus

• Main Authors: Pavin Elizabeth J (Author), Parisi Maria C (Author), Canani Luis H (Author), Azevedo Mirela J (Author), Vendramini Márcio F (Author), Dib Sérgio A (Author), Queiroz Márcia (Author), Nery Márcia (Author), Fortes Maria A (Author), Luna Ana M (Author), Marques Tatiana (Author), Monteiro Maria B (Author), Vieira Suzana M (Author), Giannella-Neto Daniel (Author), Corrêa-Giannella Maria L (Author)
• Format: Book
• Published: BMC, 2011-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Oxidative stress is recognized as a major pathogenic factor of cellular damage caused by hyperglycemia. NOX/NADPH oxidases generate reactive oxygen species and NOX1, NOX2 and NOX4 isoforms are expressed in kidney and require associat...