PCAT-1 facilitates breast cancer progression via binding to RACK1 and enhancing oxygen-independent stability of HIF-1α

• Main Authors: Jianlong Wang (Author), Xuyi Chen (Author), Haijuan Hu (Author), Mengting Yao (Author), Yanbiao Song (Author), Aimin Yang (Author), Xiuhua Xu (Author), Ning Zhang (Author), Jianzhao Gao (Author), Bin Liu (Author)
• Format: Book
• Published: Elsevier, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hypoxia induces a series of cellular adaptive responses that enable promotion of inflammation and cancer development. Hypoxia-inducible factor-1α (HIF-1α) is involved in the hypoxia response and cancer promotion, and it accumulates in hypoxia and is degraded under normoxic conditions. Here we identi...