Mosquito metallomics reveal copper and iron as critical factors for Plasmodium infection.

• Main Authors: Krystal Maya-Maldonado (Author), Victor Cardoso-Jaime (Author), Gabriela González-Olvera (Author), Beatriz Osorio (Author), Benito Recio-Tótoro (Author), Pablo Manrique-Saide (Author), Iram Pablo Rodríguez-Sánchez (Author), Humberto Lanz-Mendoza (Author), Fanis Missirlis (Author), Fidel de la Cruz Hernández-Hernández (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Iron and copper chelation restricts Plasmodium growth in vitro and in mammalian hosts. The parasite alters metal homeostasis in red blood cells to its favor, for example metabolizing hemoglobin to hemozoin. Metal interactions with the mosquito have not, however, been studied. Here, we describe the m...