SPECT/CT imaging of EGFR-positive head and neck squamous cell carcinoma patient-derived xenografts with 203Pb-PSC-panitumumab in NRG mice

• Main Authors: Nasim Sarrami (Author), Bryce Nelson (Author), Samantha Leier (Author), John Wilson (Author), Conrad Chan (Author), Jalna Meens (Author), Teesha Komal (Author), Laurie Ailles (Author), Melinda Wuest (Author), Michael Schultz (Author), Afsaneh Lavasanifar (Author), Raymond M. Reilly (Author), Frank Wuest (Author)
• Format: Book
• Published: SpringerOpen, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The objective of this research was the development and evaluation of 203Pb-labelled panitumumab (203Pb-PSC-panitumumab) as an immuno-SPECT radioligand for the detection of EGFR + head and neck squamous cell carcinoma (HNSCC) in a patient-derived xenograft (PDX) mouse model. The 5...