Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes

• Main Authors: Stane Pajk (Author), Damijan Knez (Author), Urban Košak (Author), Maja Zorović (Author), Xavier Brazzolotto (Author), Nicolas Coquelle (Author), Florian Nachon (Author), Jacques-Philippe Colletier (Author), Marko Živin (Author), Jure Stojan (Author), Stanislav Gobec (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Brain butyrylcholinesterase (BChE) is an attractive target for drugs designed for the treatment of Alzheimer's disease (AD) in its advanced stages. It also potentially represents a biomarker for progression of this disease. Based on the crystal structure of previously described highly potent, r...