2,4-Diaminothieno[3,2-d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm.

• Main Authors: Frederick A Partridge (Author), Ruth Forman (Author), Nicky J Willis (Author), Carole J R Bataille (Author), Emma A Murphy (Author), Anwen E Brown (Author), Narinder Heyer-Chauhan (Author), Bruno Marinič (Author), Daniel J C Sowood (Author), Graham M Wynne (Author), Kathryn J Else (Author), Angela J Russell (Author), David B Sattelle (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The human whipworm Trichuris trichiura is a parasite that infects around 500 million people globally, with consequences including damage to physical growth and educational performance. Current drugs such as mebendazole have a notable lack of efficacy against whipworm, compared to other soil-transmit...