Inhalation delivery dramatically improves the efficacy of topotecan for the treatment of local and distant lung cancer

• Main Authors: Philip J. Kuehl (Author), Christin M. Yingling (Author), Devon Dubose (Author), Michael Burke (Author), David A. Revelli (Author), Wenshu Chen (Author), Wendy W. Dye (Author), Steven A. Belinsky (Author), Mathewos Tessema (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Topotecan is potent anti-cancer drug approved for various malignancies but hematopoietic toxicities undermine its wider application and use of its most effective dose. This study aims to improve these limitations through inhalation-delivery. The pharmacokinetics, efficacy, and toxicity of 2-5 times...