Overcoming MDR by Associating Doxorubicin and pH-Sensitive PLGA Nanoparticles Containing a Novel Organoselenium Compound-An In Vitro Study

• Main Authors: Letícia Bueno Macedo (Author), Daniele Rubert Nogueira-Librelotto (Author), Daniela Mathes (Author), Josiele Melo de Vargas (Author), Raquel Mello da Rosa (Author), Oscar Endrigo Dorneles Rodrigues (Author), Maria Pilar Vinardell (Author), Montserrat Mitjans (Author), Clarice Madalena Bueno Rolim (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, we developed PLGA nanoparticles (NPs) as an effective carrier for 5'-Se-(phenyl)-3-(amino)-thymidine (ACAT-Se), an organoselenium compound, nucleoside analogue that showed promising antitumor activity in vitro. The PLGA NPs were prepared by the nanoprecipitation method and modifi...