Overcoming MDR by Associating Doxorubicin and pH-Sensitive PLGA Nanoparticles Containing a Novel Organoselenium Compound-An In Vitro Study

• Үндсэн зохиолчид: Letícia Bueno Macedo (Зохиогч), Daniele Rubert Nogueira-Librelotto (Зохиогч), Daniela Mathes (Зохиогч), Josiele Melo de Vargas (Зохиогч), Raquel Mello da Rosa (Зохиогч), Oscar Endrigo Dorneles Rodrigues (Зохиогч), Maria Pilar Vinardell (Зохиогч), Montserrat Mitjans (Зохиогч), Clarice Madalena Bueno Rolim (Зохиогч)
• Формат: Ном
• Хэвлэсэн: MDPI AG, 2021-12-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

In this study, we developed PLGA nanoparticles (NPs) as an effective carrier for 5'-Se-(phenyl)-3-(amino)-thymidine (ACAT-Se), an organoselenium compound, nucleoside analogue that showed promising antitumor activity in vitro. The PLGA NPs were prepared by the nanoprecipitation method and modifi...