Selection of a novel cell-internalizing RNA aptamer specific for CD22 antigen in B cell acute lymphoblastic leukemia

• Main Authors: Dario Ruiz-Ciancio (Author), Li-Hsien Lin (Author), Suresh Veeramani (Author), Maya N. Barros (Author), Diego Sanchez (Author), Ary Lautaro Di Bartolo (Author), Diego Masone (Author), Paloma H. Giangrande (Author), María Belén Mestre (Author), William H. Thiel (Author)
• Format: Book
• Published: Elsevier, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite improvements in B cell acute lymphoblastic leukemia (B-ALL) treatment, a significant number of patients experience relapse of the disease, resulting in poor prognosis and high mortality. One of the drawbacks of current B-ALL treatments is the high toxicity associated with the non-specificity...