Effects of vancomycin‐induced gut microbiome alteration on the pharmacodynamics of metformin in healthy male subjects

• Main Authors: Eunwoo Kim (Author), Andrew Hyoungjin Kim (Author), Yujin Lee (Author), Sang Chun Ji (Author), Joo‐Youn Cho (Author), Kyung‐Sang Yu (Author), Jae‐Yong Chung (Author)
• Format: Book
• Published: Wiley, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Metformin is a major treatment for type 2 diabetes. This study was conducted to investigate the impact of gut microbiome dysbiosis on the pharmacokinetics and antihyperglycemic effects of metformin. Healthy adult males aged 19-45 years with no defecation abnormalities were recruited for thi...