Effects of vancomycin‐induced gut microbiome alteration on the pharmacodynamics of metformin in healthy male subjects

• Prif Awduron: Eunwoo Kim (Awdur), Andrew Hyoungjin Kim (Awdur), Yujin Lee (Awdur), Sang Chun Ji (Awdur), Joo‐Youn Cho (Awdur), Kyung‐Sang Yu (Awdur), Jae‐Yong Chung (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Wiley, 2021-09-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Abstract Metformin is a major treatment for type 2 diabetes. This study was conducted to investigate the impact of gut microbiome dysbiosis on the pharmacokinetics and antihyperglycemic effects of metformin. Healthy adult males aged 19-45 years with no defecation abnormalities were recruited for thi...