Hippocampal PPARα Plays a Role in the Pharmacological Mechanism of Vortioxetine, a Multimodal-Acting Antidepressant

• Main Authors: Yuan Wang (Author), Jiang-Hong Gu (Author), Ling Liu (Author), Yue Liu (Author), Wen-Qian Tang (Author), Chun-Hui Ji (Author), Wei Guan (Author), Xin-Yi Zhao (Author), Ying-Fang Sun (Author), Da-Wei Xu (Author), Bo Jiang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

As a well-known multimodal-acting antidepressant, vortioxetine is thought to aim at several serotonin (5-HT) receptors and the 5-HT transporter. However, recently more and more proteins besides 5-HT are being reported to participate in the antidepressant mechanism of vortioxetine. As a widely known...