Lorcaserin Alters Serotonin and Noradrenaline Tissue Content and Their Interaction With Dopamine in the Rat Brain

• Main Authors: Giuseppe Di Giovanni (Author), Rahul Bharatiya (Author), Emilie Puginier (Author), Marta Ramos (Author), Salomé De Deurwaerdère (Author), Abdeslam Chagraoui (Author), Philippe De Deurwaerdère (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lorcaserin is a preferential serotonin2C receptor (5-HT2CR) agonist effective to treat obesity that has also recently been proposed to treat addiction and epilepsy. Central dopamine (DA) mechanisms are likely involved in the lorcaserin mechanism of action, but other monoamines 5-HT and noradrenaline...