Pharmacokinetic herb-drug interactions: Altered systemic exposure and tissue distribution of ciprofloxacin, a substrate of multiple transporters, after combined treatment with Polygonum capitatum Buch.-Ham. ex D. Don extracts

• Principais autores: Ziqiang Li (Autor), Xi Du (Autor), Shuang Tian (Autor), Shanshan Fan (Autor), Xurui Zuo (Autor), Yanfen Li (Autor), Ruihua Wang (Autor), Baohe Wang (Autor), Yuhong Huang (Autor)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Background: Combination of Polygonum capitatum Buch.-Ham. ex D. Don extract (PCE) and ciprofloxacin (CIP) was commonly prescribed in the treatment of urinary tract infections. Their pharmacokinetic herb-drug interactions (HDIs) were focused in this study to assess potential impact on the safety and...