Pre-Clinical Investigations of the Pharmacodynamics of Immunogenic Smart Radiotherapy Biomaterials (iSRB)

• Main Authors: Michele Moreau (Author), Shahinur Acter (Author), Lindokuhle M. Ngema (Author), Noella Bih (Author), Gnagna Sy (Author), Lensa S. Keno (Author), Kwok Fan Chow (Author), Erno Sajo (Author), Oscar Nebangwa (Author), Jacques Walker (Author), Philmo Oh (Author), Eric Broyles (Author), Wilfred Ngwa (Author), Sayeda Yasmin-Karim (Author)
• Format: Book
• Published: MDPI AG, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The use of an immunogenic smart radiotherapy biomaterial (iSRB) for the delivery of anti-CD40 is effective in treating different cancers in animal models. This study further characterizes the use of iSRBs to evaluate any associated toxicity in healthy C57BL6 mice. iSRBs were fabricated using a poly-...