Potent Inhibition of Human Cytochrome P450 3A4 by Biflavone Components from Ginkgo Biloba and Selaginella Tamariscina

• Egile Nagusiak: Bo Wang (Egilea), Chao Shi (Egilea), Lei Feng (Egilea), Wei Pan (Egilea), Xiang-Ge Tian (Egilea), Cheng-Peng Sun (Egilea), Chao Wang (Egilea), Jing Ning (Egilea), Xia Lv (Egilea), Yan Wang (Egilea), Qian-Hui Yuan (Egilea), Rui-Xuan Guan (Egilea), Hou-Li Zhang (Egilea), Xiao-Chi Ma (Egilea), Tong-Hui Ma (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

CYP3A4-mediated Phase I biotransformation is the rate-limiting step of elimination for many commonly used clinically agents. The modulatory effects of herbal medicines on CYP3A4 activity are one of the risk factors affecting the safe use of drug and herbal medicine. In the present study, the inhibit...