Neuroprotective Role of α-Lipoic Acid in Iron-Overload-Mediated Toxicity and Inflammation in In Vitro and In Vivo Models

• Main Authors: Giuseppe Carota (Author), Alfio Distefano (Author), Mariarita Spampinato (Author), Cesarina Giallongo (Author), Giuseppe Broggi (Author), Lucia Longhitano (Author), Giuseppe A. Palumbo (Author), Rosalba Parenti (Author), Rosario Caltabiano (Author), Sebastiano Giallongo (Author), Michelino Di Rosa (Author), Riccardo Polosa (Author), Vincenzo Bramanti (Author), Nunzio Vicario (Author), Giovanni Li Volti (Author), Daniele Tibullo (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hemoglobin and iron overload is considered the major contributor to intracerebral hemorrhage (ICH)-induced brain injury. Accumulation of iron in the brain leads to microglia activation, inflammation and cell loss. Current available treatments for iron overload-mediated disorders are characterized by...