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Treatment of Bloodstream Infections Due to Gram-Negative Bacteria with Difficult-to-Treat Resistance

The rising incidence of bloodstream infections (BSI) due to Gram-negative bacteria (GNB) with difficult-to-treat resistance (DTR) has been recognized as a global emergency. The aim of this review is to provide a comprehensive assessment of the mechanisms of antibiotic resistance, epidemiology and tr...

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Main Authors: Matteo Bassetti (Author), Antonio Vena (Author), Chiara Sepulcri (Author), Daniele Roberto Giacobbe (Author), Maddalena Peghin (Author)
Format: Book
Published: MDPI AG, 2020-09-01T00:00:00Z.
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Summary:The rising incidence of bloodstream infections (BSI) due to Gram-negative bacteria (GNB) with difficult-to-treat resistance (DTR) has been recognized as a global emergency. The aim of this review is to provide a comprehensive assessment of the mechanisms of antibiotic resistance, epidemiology and treatment options for BSI caused by GNB with DTR, namely extended-spectrum Beta-lactamase-producing <i>Enterobacteriales</i>; carbapenem-resistant <i>Enterobacteriales</i>; DTR <i>Pseudomonas aeruginosa</i>; and DTR <i>Acinetobacter baumannii</i>.
Item Description:10.3390/antibiotics9090632
2079-6382

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