The Analysis of Key Factors Related to ADCs Structural Design

• Main Authors: Haichao Tang (Author), Yan Liu (Author), Zhaojin Yu (Author), Mingli Sun (Author), Lu Lin (Author), Wensi Liu (Author), Qiang Han (Author), Minjie Wei (Author), Ying Jin (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antibody-drug conjugates (ADCs) have developed rapidly in recent decades. However, it is complicated to map out a perfect ADC that requires optimization of multiple parameters including antigens, antibodies, linkers, payloads, and the payload-linker linkage. The therapeutic targets of the ADCs are e...