Transient Downregulation of Nanog and Oct4 Induced by DETA/NO Exposure in Mouse Embryonic Stem Cells Leads to Mesodermal/Endodermal Lineage Differentiation

• Главные авторы: Sergio Mora-Castilla (Автор), Juan R. Tejedo (Автор), Rafael Tapia-Limonchi (Автор), Irene Díaz (Автор), Ana B. Hitos (Автор), Gladys M. Cahuana (Автор), Abdelkrim Hmadcha (Автор), Franz Martín (Автор), Bernat Soria (Автор), Francisco J. Bedoya (Автор)
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• Опубликовано: Hindawi Limited, 2014-01-01T00:00:00Z.
• Предметы: article
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The function of pluripotency genes in differentiation is a matter of investigation. We report here that Nanog and Oct4 are reexpressed in two mouse embryonic stem cell (mESC) lines following exposure to the differentiating agent DETA/NO. Both cell lines express a battery of both endoderm and mesoder...