Transient Downregulation of Nanog and Oct4 Induced by DETA/NO Exposure in Mouse Embryonic Stem Cells Leads to Mesodermal/Endodermal Lineage Differentiation

• Main Authors: Sergio Mora-Castilla (Author), Juan R. Tejedo (Author), Rafael Tapia-Limonchi (Author), Irene Díaz (Author), Ana B. Hitos (Author), Gladys M. Cahuana (Author), Abdelkrim Hmadcha (Author), Franz Martín (Author), Bernat Soria (Author), Francisco J. Bedoya (Author)
• Format: Book
• Published: Hindawi Limited, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The function of pluripotency genes in differentiation is a matter of investigation. We report here that Nanog and Oct4 are reexpressed in two mouse embryonic stem cell (mESC) lines following exposure to the differentiating agent DETA/NO. Both cell lines express a battery of both endoderm and mesoder...