Transient Downregulation of Nanog and Oct4 Induced by DETA/NO Exposure in Mouse Embryonic Stem Cells Leads to Mesodermal/Endodermal Lineage Differentiation

• Hoofdauteurs: Sergio Mora-Castilla (Auteur), Juan R. Tejedo (Auteur), Rafael Tapia-Limonchi (Auteur), Irene Díaz (Auteur), Ana B. Hitos (Auteur), Gladys M. Cahuana (Auteur), Abdelkrim Hmadcha (Auteur), Franz Martín (Auteur), Bernat Soria (Auteur), Francisco J. Bedoya (Auteur)
• Formaat: Boek
• Gepubliceerd in: Hindawi Limited, 2014-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

The function of pluripotency genes in differentiation is a matter of investigation. We report here that Nanog and Oct4 are reexpressed in two mouse embryonic stem cell (mESC) lines following exposure to the differentiating agent DETA/NO. Both cell lines express a battery of both endoderm and mesoder...