IgG Galactosylation status combined with MYOM2-rs2294066 precisely predicts anti-TNF response in ankylosing spondylitis

• Main Authors: Jing Liu (Author), Qi Zhu (Author), Jing Han (Author), Hui Zhang (Author), Yuan Li (Author), Yanyun Ma (Author), Dongyi He (Author), Jianxin Gu (Author), Xiaodong Zhou (Author), John D. Reveille (Author), Li Jin (Author), Hejian Zou (Author), Shifang Ren (Author), Jiucun Wang (Author)
• Format: Book
• Published: BMC, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Tumor necrosis factor (TNF) blockers have a high efficacy in treating Ankylosing Spondylitis (AS), yet up to 40% of AS patients show poor or even no response to this treatment. In this paper, we aim to build an approach to predict the response prior to clinical treatment. Methods...